Tetrapyrroles and derivatives
Cayman Chemical ZInc ProtoporphyrIn-9 10mg
A competitive inhibitor of heme oxygenase that also inhibits soluble guanylyl cyclase and inactivates the NOS isoforms nNOS, iNOS, and eNOS (IC50s = 0.8, 4, and 5 μM, respectively); used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in hyperbilirubinemia
Frontier Specialty Chemicals 1G MESO-TETRA(P-HYDROXYPHENYL)
meso-Tetra(p-hydroxyphenyl)porphine; CAS: 51094-17-8; 1g
Frontier Specialty Chemicals 250MG MESO-TETRA(4-CARBOXYPHEN
meso-Tetra(4-carboxyphenyl)porphine; CAS: 14609-54-2; 250mg
Apexbio Technology LLC Chlorin e6(Synonyms: Ce6, Chlorophyllin e6, Chlorophyll derivative e6, Chlorin-e6, Chlorin e-6), 250mg, CAS: 19660-77-6.
Chlorin e6 (Ce6 CAS 19660-77-6) is a second-generation photosensitizer utilized in photodynamic therapy (PDT) research with demonstrated anticancer activity when activated by laser irradiation Upon irradiation Ce6 generates reactive oxygen species mediating cytotoxic effects and cellular apoptosis In mouse models intravenous administration of Ce6 (2 5 10 mg/kg) combined with irradiation (50 200 J/cm ) resulted in complete elimination of implanted fibrosarcomas In clinical trials for bronchogenic superficial squamous cell carcinoma Ce6-based PDT (40 mg/m 100 J/cm ) produced complete response rates up to 82 9% underscoring its utility for cancer therapy studies
Medchemexpress LLC Biliverdin | 114-25-0 | MFCD00870216 | 70.0% | 582.65 | C33H34N4O6 | 5 MG
Biliverdin is a tetrapyrrolic bile pigment produced during heme catabolism and provided as a research reagent for biochemical and cellular studies. It is investigated for antioxidant, anti-inflammatory, and immunomodulatory effects and for its role in heme metabolism and tissue protection. For research use only.
- Endogenous metabolite used in biochemical and cell biology research.
- Exhibits antioxidant, anti-inflammatory, and immunosuppressant properties.
- Soluble in DMSO at about 3 mg/mL; ultrasonic warming recommended.
- Store at -20°C protected from light; in solvent store at -80°C for long-term stability.
- Available in small milligram quantities suitable for laboratory experiments.
Medchemexpress LLC Bilirubin oxidase | 80619-01-8 | 500 U
Bilirubin oxidase (BOD) is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. It participates in the metabolism of porphyrin and chlorophyll and is widely used in biochemical research as a catalyst for oxygen reduction.
- Catalyzes the oxidation of bilirubin to biliverdin
- Reduces molecular oxygen to water
- Participates in porphyrin and chlorophyll metabolism
- Functions as an oxygen reduction catalyst in biochemical research
- Appearance as a solid
- Color ranges from light blue to blue
- Intended for research use only
- Unit defined as the amount of enzyme converting 1 μmol of bilirubin into biliverdin per minute at 25 °C and pH 8.0
Abcam Bisindolylmaleimide II, PKC inhibitor, 5MG
MW 438.5 Da, Purity >97%. Potent, selective ATP-competitive PKC inhibitor (IC₅₀ values are 0.01, 0.75 and 2 μM for PKC, phosphorylase kinase and PKA respectively). Potent noncompetitive nAChR antagonist (IC₅₀ = 0.03 μM, catecholamine secretion in nicotine-stimulated PC-12 cells). Shows more potent antinicotinic effects than Bisindolylmaleimide IV (ab144208) and V (ab144205). Induces apoptosis and shows antiproliferative effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (±)-SKF38393 hydrochloride, D1-like dopamine receptor agonist, 100MG
MW 291.77 Da, Purity >98%. D1-like dopamine receptor agonist. pKi values are 9 (D1), 6.8 (D2), 5.3 (D3), 6.0 (D4) and 9.3 (D5). Ki values are 151 and 2364 nM for D1-like and D2-like dopamine receptors, respectively. Centrally active upon systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Rhodadyn™ B10, Negative control for Rhodadyn™ C10, 5MG
MW 322.44 g/mol, Purity >98%. Negative control for Rhodadyn™ C10 (ab120795). Demonstrates no significant inhibition of dynamin I or dynamin II in vitro GTPase activity at concentrations up to 300 μM and has no effect on clathrin-mediated endocytosis of transferrin when applied for 30 minutes to U2OS cells in culture. Robertson J et al. The rhodadyn™ a new class of small molecule inhibitors of dynamin GTPase. ACS Med. Chem (2012).
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168077 maleate, D4 agonist, 50MG
MW 450.49 g/mol, Purity >98%. Potent, selective D₄ dopamine receptor agonist. Displays >400-fold selectivity over D₂ and >300-fold selectivity over D₃ subtypes (Ki values are 11.9, 2540, and 1050 nM for D₄, D₃, and D₂ receptors, respectively). Reverses object recognition deficits.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 4-Thiouridine, RNA synthesis inhibitor, 5MG
MW 260.27 Da, Purity >99%. Ribonucleoside (Uridine ab143255) analog. Antisense agent. RNA synthesis inhibitor. Modifies oligos slated for RNA. Induces p53 and inhibits proliferation. Metabolically labels RNA for stability studies.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ODQ, NO-sensitive guanylyl cyclase inhibitor, 50MG
MW 187.15 Da, Purity >99%. Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam UDP-glucose, Highly P2Y14 agonist, 100MG
MW 610.27 Da. Highly potent, endogenous P2Y14 agonist (EC50 = 82 nM). Involved in modulation of gastric function. UDP also available (ab120383).
The product is subject to the following: Abcam Restricted Use Statement