Tetrapyrroles and derivatives
Abcam Zaprinast, cGMP phosphodiesterase inhibitor, 10MG
MW 271.28 g/mol, Purity >98%. Specific cGMP phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15 (PDE6), 0.76 (PDE5), 12 (PDE11) and 29 μM (PDE9)). Reputed GPR35 agonist (EC₅₀ values are 16 and 840 nM at rat and human GPR35 receptors, respectively). Important mediator for a variety of cellular processes including vasodilation.
The product is subject to the following: Abcam Restricted Use Statement
Abcam L-745870 trihydrochloride, brain penetrant D4 antagonist, 50MG
MW 436.21 g/mol, Purity >99%. Highly potent and selective D₄ antagonist (Ki values are 0.43, 2300 and 960 nM at D₄, D₃ and D₂, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam EMD 386088 hydrochloride, 5-HT6 agonist, 10MG
MW 283.2 Da, Purity >98%. Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 50MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
Abcam ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist, 5MG
MW 283.41 Da, Purity >99%. Selective protease-activated receptor 2 (PAR2) antagonist (IC₅₀ = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Frontier Specialty Chemicals 50MG 5-MONO(4-CARBOXYPHENYL)-1
5-mono(4-carboxyphenyl)-10,15,20-triphenyl porphyrin; CAS: 95051-10-8; 50mg
Abcam MPEP hydrochloride, mGlu5 antagonist, 10MG
MW 229.7 Da, Purity >99%. Subtype selective and potent non-competitive mGlu₅ antagonist (IC₅₀ = 36 nM). Central effects following systemic administration in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (±)-Miconazole nitrate, Imidazole antifungal agent, 1G
MW 479.1 Da, Purity >99%. Imidazole antifungal agent. Inhibits fungal membrane ergosterol biosynthesis. Increases reactive oxygen species production.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 408124, non-peptide O x 1 antagonist, 10MG
MW 356.4 Da, Purity >97%. Selective, non-peptide orexin receptor 1 (OX1) antagonist (Ki = 26.9 nM). Displays 50-fold selectivity over OX2 (Kb values are 21.7 and 1405 nM for OX1 and OX2, respectively).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Genipin, Cell-permeable uncoupling protein 2 inhibitor, 100MG
MW 226.23 g/mol, Purity >99%. Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
The product is subject to the following: Abcam Restricted Use Statement
Abcam HTMT (Histamine trifluoromethyl toluidide) dimaleate, H1/H2 receptor agonist, 10MG
MW 628.6 Da, Purity >99%. H1/H2 receptor agonist (Ki = 1.2 µM). More potent than histamine (ab120734). Activates IP3/Ca2+ signaling and induces proliferation of small cholangiocytes. Active *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Chem-Impex International, Inc. Hemin (from porcine) | 16009-13-5 | MFCD00010726 | 25G
Hemin (from porcine), 16009-13-5, MFCD00010726, 25G
Abcam SB 216763, GSK3 inhibitor, 1MG
MW 371.2 Da, Purity >98%. Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Desmethyl YM298198 hydrochloride, Analogue of mGlu1 antagonist YM298198, 10MG
MW 364.9 Da, Purity >99%. Derivative of mGlu1 antagonist YM298198 (ab120015). Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Pimobendan (Vetmedin), Ca2+ channel sensitizer, 10MG
MW 334.4 Da, Purity >99%. Ca2+ channel sensitizer. Selective PDE3 inhibitor. Inhibits platelet aggregation. Shows antithrombotic, antihypertensive, potent inotropic and vasodilatory effects *in vivo.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement